Interview lygature: progress on data storage and analysis enablement
interview
Introduction
In our latest interview, we had the opportunity to speak with Jan-Willem Boiten, the leader of Work Package 2 (WP2) in the Immune-Image project. Jan-Willem shared exciting insights into the progress and future plans of his work package, highlighting the strides made in developing a robust data infrastructure that underpins the project’s clinical and imaging data needs. Jan-Willem’s insights provide a clear roadmap for the remainder of the project, focused on solidifying their achievements and laying the groundwork for future innovations that build on the Immune-Image results.
Could you share an update on your recent progress within your work package?
“The over-all data infrastructure required for Immune-image has been implemented based on well-accepted tools such as REDCap (clinical data), XNAT (imaging data), Immune-Image Repository (Protocols and SOPs), Molgenis Catalogue (meta data) and IMIOMICs (image analysis), the maturity still varying from demonstrator-level to production-grade. A data sharing taskforce has been established with representatives from all work packages to discuss the current data sharing needs and preferences, how these will evolve towards the end of the project, and to explore options for cost-effective long-term data storage and sustainability beyond the project duration.
The SME partner Antaros Medical has executed further analytic work on the IMIOMICS image analysis tool using data from the IMPACT-MBC study (low-dose CT, FDG PET and two experimental PET-tracers). A manuscript for publication is currently being prepared.
The academic partner Amsterdam UMC has been developing and implementing preclinical and clinical PBPK models.”
What key areas are you concentrating on until the end of the project?
“Rather than focusing on further maturation of the specific Immune-Image data infrastructure solutions, we will give priority to exploring options for transitioning our data to a sustainable environment that will enable the Immune-Image partners to use the data also beyond the project duration. The priorities for this work will be driven by the data sharing taskforce and the Immune-Image sustainability working group. For the image analysis tools we aim to publish the results and provide a report on the evaluation of quantitative image analysis tools.”
From your perspective, how do you think we can further build on the results of the Immune-Image project?
“We aim to ensure that critical data from Immune-Image will be available for any future initiative that is building onto the Immune-Image results. We are therefore already in close contact with the Immune-Image sustainability working group. Also, our partner Antaros Medical will continue to build on the Imiomics analytics tool to be used as a, potentially very valuable, tool to analyse PET-tracer based biomarkers in clinical studies.”
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