by Janneke de Haan | Nov 21, 2023 | News, Publications
Unveiling the potential of a macrophage-targeted PET tracer: A first-in-human study Introduction The human immune system contains a complex network of cells and organs, each with their own unique functions. Within this intricate tapestry, macrophages play an...
by Janneke de Haan | Aug 15, 2023 | Publications
Phase I Study of [68Ga]Ga-Anti-CD206-sdAb for PET/CT Assessment of Protumorigenic Macrophage Presence in Solid Tumors (MMR Phase I) ABSTRACT Purpose Macrophages play an important role throughout the body. Antiinflammatory macrophages expressing the macrophage mannose...
by Janneke de Haan | Mar 20, 2023 | Publications
Validation of simplified uptake measures against dynamic Patlak Ki for quantification of lesional 89Zr-Immuno-PET antibody uptake ABSTRACT Purpose Positron emission tomography imaging of zirconium-89-labelled monoclonal antibodies (89Zr-Immuno-PET) allows for...
by Janneke de Haan | Oct 28, 2022 | Publications
Interrogating Glioma-Associated Microglia and Macrophage Dynamics Under CSF-1R Therapy with Multitracer In Vivo PET/MRI ABSTRACT Purpose Glioma-associated microglia and macrophages (GAMMs) are key players in creating an immunosuppressive microenvironment. They can be...
by Anne-Fleur | Oct 28, 2022 | Publications
Optimal imaging time points considering accuracy and precision of Patlak linearization for 89Zr-immuno-PET: a simulation study ABSTRACT Purpose Zirconium-89-immuno-positron emission tomography (89Zr-immuno-PET) has enabled visualization of zirconium-89 labelled...
by Anne-Fleur | Oct 1, 2022 | Publications
Radiomic Signatures Associated with CD8+ Tumour-Infiltrating Lymphocytes: A Systematic Review and Quality Assessment Study ABSTRACT Simple Summary: Immune checkpoint inhibitors can be effective drugs to treat cancer. However, only a minority of patients derive...
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